Fabrication of Cell-Laden Macroporous Biodegradable Hydrogels with Tunable Porosities and Pore Sizes

Cell-adhesive and mechanically tunable glucose-based biodegradable hydrogels.

The development of materials with biomimetic mechanical and biological properties is of great interest for regenerative medicine applications. In particular, hydrogels are a promising class of biomaterials due to their high water content, which mimics that of natural tissues. We have synthesized a hydrophilic biodegradable polymer, designated poly(glucose malate)methacrylate (PGMma), which is c...

Cell-laden microengineered and mechanically tunable hybrid hydrogels of gelatin and graphene oxide.

Incorporating graphene oxide inside GelMA hydrogels enhances their mechanical properties and reduces UV-induced cell damage while preserving their favorable characteristics for 3D cell encapsulation. NIH-3T3 fibroblasts encapsulated in GO-GelMA microgels demonstrate excellent cellular viability, proliferation, spreading, and alignment. GO reinforcement combined with a multi-stacking approach of...

High-temperature post-processing treatment of silica nanofoams of controlled pore sizes and porosities

Cell-laden microengineered gelatin methacrylate hydrogels.

The cellular microenvironment plays an integral role in improving the function of microengineered tissues. Control of the microarchitecture in engineered tissues can be achieved through photopatterning of cell-laden hydrogels. However, despite high pattern fidelity of photopolymerizable hydrogels, many such materials are not cell-responsive and have limited biodegradability. Here, we demonstrat...

Fabrication of tunable spherical colloidal crystals immobilized in soft hydrogels.